Synchrotron FTIR analysis of Articular Calcium Containing Crystals
نویسندگان
چکیده
منابع مشابه
Chemical Imaging of In Vitro Models of Calcium Crystal Formation
Problems in accurately identifying calcium-containing crystals has slowed progress towards understanding the role of these important particulates in osteoarthritis. Synchrotron FTIR analysis has been useful in studying mineral formation in bone. We set out to determine if it could be used in synovial fluid and tissue culture models to identify and characterize calciumcontaining crystals. Discar...
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Calcium (Ca(2+))-containing crystals (CCs), including basic Ca(2+) phosphate (BCP) and Ca(2+) pyrophosphate dihydrate (CPPD) crystals, are associated with severe forms of osteoarthritis (OA). Growing evidence supports a role for abnormal articular cartilage mineralization in the pathogenesis of OA. However, the role of Ca(2+) compounds in this mineralization process remains poorly understood. S...
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The deposition of calcium-containing crystals in articular tissues is probably an underrecognized event. Clinical observations indicate that exaggerated and uniquely distributed cartilage degeneration is associated with these deposits. Perhaps the most compelling argument favoring a role for crystals in causing osteoarthritis stems from their in vitro effects on articular tissues. In this revie...
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Side eVects of intra-articular hyaluronate injection include aseptic acute arthritis, which develops within hours after injection. Based on standard crystal analysis, calcium crystal shedding has been postulated to explain this complication. However, it is not known whether apatite crystals or low amounts of calcium pyrophosphate dihydrate (CPPD) crystals are also involved as to determine this ...
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